Architectural Correlates of Myocardial Conduction: Changes to the Topography of Cellular Coupling, Intracellular Conductance and Action Potential Propagation with Hypertrophy in Guinea-Pig Ventricular Myocardium Running title: Fry et al.; conduction velocity in ventricular hypertrophy
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Architectural correlates of myocardial conduction: changes to the topography of cellular coupling, intracellular conductance, and action potential propagation with hypertrophy in Guinea-pig ventricular myocardium.
BACKGROUND We tested the hypothesis that alterations to action potential conduction velocity (CV) and conduction anisotropy in left ventricular hypertrophy are associated with topographical changes to gap-junction coupling and intracellular conductance by measuring these variables in the same preparations. METHODS AND RESULTS Left ventricular papillary muscles were excised from aortic-banded ...
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BACKGROUND Acute ischemia often occurs in cardiac tissue that has prior injury, resulting in spatially inhomogeneous distributions of membrane properties and intercellular coupling. Changes in action potential conduction with ischemia, which can be associated with release of catecholamines, may be particularly important in tissue that has discontinuous conduction resulting from prior infarction...
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BACKGROUND Gap junction resistivity, R(j), has been proposed as a key determinant of conduction velocity (CV). However, studies in connexin-gene knockout mice demonstrated significant CV slowing only with near-complete connexin deletion, and these findings led to the concept of a significant redundancy of myocardial gap junctions. We challenged this prevailing concept and addressed the hypothes...
متن کاملThe role of angiotensin receptor-1 blockade on electromechanical changes induced by left ventricular hypertrophy and its regression.
OBJECTIVE The aims of this study were to: i) investigate the role of angiotensin in mediating changes to myocardial electromechanical properties during the development and regression of left ventricular hypertrophy (LVH) generated by constriction of the thoracic aorta; ii) identify any role of angiotensin-1 receptor blockade on ameliorating changes to these electromechanical properties. METHO...
متن کاملElectrophysiological effects accompanying regression of left ventricular hypertrophy.
OBJECTIVE The aim of this study was to investigate changes following regression of left ventricular hypertrophy (LVH). METHODS Electrophysiolological changes were recorded in isolated guinea-pig myocardial preparations. LVH was induced by constriction of the thoracic aorta and regression was followed after removal of the constriction. Sham-operated animals served as controls. RESULTS During...
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تاریخ انتشار 2014